Zhi Zhu


Contact Information

  • Email Address: zhuzhi@xmu.edu.cn


Aug. 2006- May 2011

Ph.D. University of Florida, Analytical Chemistry, Advisor: Prof. Weihong Tan

Sep. 2002 – July 2006

B. S. Peking University, Chemistry

Professional Experiences

Nov 2016-present

College of Chemistry and Chemical Engineering, Xiamen University, Distinguished Professor

Aug 2015-present

College of Chemistry and Chemical Engineering, Xiamen University, Professor

Jan 2012-Aug 2015

College of Chemistry and Chemical Engineering, Xiamen University, Associate Professor

Aug 2011-Jan 2012

College of Chemistry and Chemical Engineering, Xiamen University, Assistant Professor

Research Interests



Point-of-care testing

Single-cell analysis


2016   Youth in Chemistry Award of Chinese Chemical Society

2014   The National Science Foundation of China for Excellent Young Scholars

2010   Chinese Government Award for Outstanding Students Aboard

2009   ACS Division of Analytical Chemistry Nine-Month Graduate Fellowship


[1]    Huang, D; Lin, B; Song, Y; Guan, Z; Cheng J; Zhu, Z*; Yang, C*. “Staining Traditional Colloidal Gold Test Strips with Pt Nanoshell Enables Quantitative Point-of-Care Testing with Simple and Porta-ble Pressure Meter Readout.” ACS Appl. Mater. Interfaces, DOI: 10.1021/acsami.8b15562

[2]    Guo, J; Gao, M; Song, Y*; Lin, L; Zhao, K; Tian, T; Liu, D; Zhu, Z*; Yang, C. “An allosteric-probe for detection of alkaline phosphatase activity and its application in immunoassay.” Frontiers Chemistry, 2018, 6, 618.

[3]    Li, X; Zhang, D; Zhang, H; Guan, Z; Song, Y; Liu, R; Zhu, Z*; Yang, C. “A Microwell Array Method for Rapid Generation of Uniform Agarose Droplets and Beads for Single Molecule Analysis.” Anal. Chem., 2018, 90, 2570–2577.

[4]    Ma, Y; Mao, Y; An, Y; Tian, T; Zhang, H; Yan, J; Zhu, Z*; Yang, C. “Target-Responsive DNA Hydrogel for Non-enzymatic and Visual Detection of Glucose.” Analyst, 2018, 143, 1679-1684. 

[5]    Tan, Y; Liu, W; Zhu, Z*; Lang, L; Wang, J; Huang, M; Yang, C*. “Selection and identification of transferrin receptor-specific peptides as recognition probes for cancer cells.” Anal Bioanal Chem, 2018, 410, 1071-1077.

[6]    Gao, M; Guo, J; Song, Y*; Zhu, Z*; Yang, C*. “Detection of T4 Polynucleotide Kinase via Allosteric Aptamer Probe Platform.” ACS Appl. Mater. Interfaces, 2017, 9, 38356–38363.

[7]    Liu, D; Jia, S; Zhang, H; Ma, Y; Guan, Z; Li, J; Zhu, Z*; Ji, T; Yang, C*. Integrating Target-Responsive Hydrogel with Pressuremeter Readout Enables Simple, Sensitive, User-friendly, Quantitative Point-of-Care Testing, ACS Appl. Mater. Interfaces, 2017, 9, 22252-22258.

[8]    Zhu, Z; Yang, C*. Hydrogel Droplet Microfluidics for High-Throughput Single Molecule/Cell Analysis.” Acc. Chem. Res., 2017, 50, 22–31.

[9]    Xie, Y; Wei, X; Yang, Q; Guan, Z; Liu, D; Liu, X; Zhou, L; Zhu, Z*; Lin, Z*; Yang, C*. “Shake&Read Distance-based Microfluidic Chip as a Portable Quantitative Readout Device for Highly Sensitive Point-of-Care Testing.” Chem. Commun., 2016, 52, 13377-13380.

[10]Ma, Y; Mao, Y; Huang, D; He, Z; Yan, J; Tian, T; Shi, Y; Song, Y; Li, X; Zhu, Z*; Zhou, L; Yang, C. “Portable Visual Quantitative Detection of Aflatoxin B1 Using a Target-Responsive Hydrogel and Distance-Readout Microfluidic Chip.” Lab Chip, 2016, 16, 3097-3104.

[11]Huang, Y; Fang, L; Zhu, Z*; Ma, Y; Zhou, L; Chen, X; Xu, D; Yang, C*. “Design and synthesis of target-responsive hydrogel for portable visual quantitative detection of uranium with a microfluidic distance-based readout device.” Biosensors Bioelectronics, 2016, 85, 496-502.

[12]Tan, Y; Tian, T; Liu, W; Zhu, Z*; Yang, C. “Advance in phage display technology for bioanalysis.” Biotechnol J, 2016, 11, 732-745.

[13]Tian, T; Li, J; Song,Y; Zhou, L; Zhu, Z*; Yang, C*. “Distance-based Microfluidic Quantitative Detection Methods for Point-of-Care Testing.” Lab Chip, 2016, 16, 1139-1151.

[14]Zhang, W; Zu, X; Song, Y; Zhu, Z*; Yang, C*. “Detection of DNA Methyltransferase Activity using Allosteric Molecular Beacons.” Analyst, 2016, 141, 579-584.

[15]Tian, T; Wei, X; Jia, S; Zhang, R; Li, J; Zhu, Z*; Zhang, H; Ma, Y; Lin, Z; Yang, C.* “Integration of target responsive Hydrogel with cascaded enzymatic Reactions and microfluidic paper-based analytic Devices (µPADs) for point-of-care testing (POCT).” Biosensors Bioelectronics, 2016, 77, 537-542.

[16]Zhu, Z#; Guan, Z#; Liu, D#; Jia, S; Li, J; Lei, Z; Lin, S; Ji, T; Tian, Z; Yang, C*. “Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis.” Angew. Chem. Int. Ed., 2015, 54, 10448-10453. (Frontipiece Paper)

[17]Liu, R; Huang, Y; Ma, Y; Jia, S; Gao, M; Li, J; Zhang, H; Xu, D; Wu, M; Chen, Y; Zhu, Z*; Yang C*. “Design and Synthesis of Target-Responsive Aptamer-Crosslinked Hydrogel for Visual Quantitative Detection of Ochratoxin A.” ACS Appl. Mater. Interfaces, 2015, 7, 6982-6990.

[18]Huang, Y; Ma, Y; Chen, Y; Wu, X; Fang, L; Zhu, Z*; Yang, C*. “Target-Responsive DNAzyme Crosslinked Hydrogel for Visual Quantitative Detection of Lead.” Anal. Chem., 2014, 86, 11434–11439.

[19]Ke, G; Zhu, Z*; Wang, W; Zou, Y; Guan, Z; Jia S; Zhang, H; Wu, X; Yang, C*. “A Cell Surface-Anchored Ratiometric Fluorescent Probe for Extracellular pH Sensing”, ACS Appl. Mater. Interfaces, 2014, 6 15329–15334.

[20]Zhu, Z#; Guan, Z#; Jia, S#; Lei, Z; Lin, S; Zhang, H; Ma, Y; Tian, Z-Q; Yang, C*. “Au@Pt Nanoparticle Encapsulated Target-responsive Hydrogel with Volumetric Bar-chart Chip Readout for Quantitative Point-of-care Testing.” Angew. Chem. Int. Ed., 2014, 53, 12503–12507

[21]Lin, H; Zhang, W; Jia, S; Guan, Z; Yang, C; Zhu, Z*.Microfluidic Approaches to Rapid and Efficient Aptamer Selection.” Biomicrofluidics, 2014, 8, 041501.

[22]Zhu, Z#; Song, Y#; Li, C#; Zou, Y; Zhu, L; An, Y; Yang, C*. “Monoclonal Surface Display SELEX for Simple, Rapid, Efficient and Cost-Effective Aptamer Enrichment and Identification.” Anal. Chem., 2014, 86, 5881-5888.

[23]Lin, X; Cui, L; Huang, Y; Lin, Y; Xie, Y; Zhu, Z*; Yin, B; Chen, X; Yang, C*. “Carbon Nanoparticle-Protected Aptamers for Highly Sensitive and Selective Detection of Biomolecules Based on Nuclease-Assisted Target Recycling Signal Amplification.” Chem. Commun., 2014, 50, 7646-7648.

[24]Zhang, H; Song, Y; Zou, Y; Ge, Y; An, Y; Ma, Y; Zhu, Z*; Yang, C*. “A Diazirine-Based Photoaffinity Probe for Facile and Efficient Aptamer-Protein Covalent Conjugation.” Chem. Commun., 2014, 50, 4891-4894.

[25]Guan, Z#; Jia S#; Zhu, Z#; Zhang, M; Yang, C*. “Facile and Rapid Generation of Large-scale Micro-collagen-gel Array for Long-term Single Cell 3D Culture and Cell Proliferation Heterogeneity Analysis.” Anal. Chem., 2014, 86, 2789-2797.

[26]Cui, L; Zhu, Z*; Lin, L; Zhang, H; Guan, Z; Yang, C*. “A T7 Exonuclease-Assisted Cyclic Enzymatic Amplification Method Coupled with Rolling Circle Amplification: A Dual-amplification Strategy for Sensitive and Selective MicroRNA Detection.” Chem. Commun., 2014, 50, 1576-1578. 

[27]  Cui, L; Ke, G; Lin, X; Song, Y; Zhang, H; Guan, Z; Zhu, Z*; Yang, C. “Cyclic Enzymatic Amplification Method (CEAM) Based on Exonuclease III for Highly Sensitive Bioanalysis.” Methods, 2013, 63, 202-211.

[28]Cui, L; Song, Y; Ke, G; Guan, Z; Zhang, H; Lin, Y; Huang, Y; Zhu, Z*; Yang, C*. “Graphene Oxide Protected Nucleic Acid Probes for Bioanalysis and Biomedicine.” Chem. Eur. J., 2013, 19, 10442-10451.

[29]  Lin, X; Zhang, C; Huang, Y; Zhu, Z*; Chen, X; Yang, C*. “Backbone-modified Molecular Beacons for highly Sensitive and Selective Detection of microRNAs Based on Duplex Specific Nuclease Signal Amplification.” Chem. Commun., 2013, 49, 7243-7245.

[30]  Song, Y; Zhu, Z*; An, Y; Zhang, W; Zhang, H; Liu, D; Yu, C;Duan, W*; Yang, C*. “Selection of DNA Aptamers against Epithelial Cell Adhesion Molecule for Cancer Imaging and Circulating Tumor Cell Capturing.” Anal. Chem., 2013, 85, 4141-4149.

[31]  Yan, L#; Zhu, Z#; Zou, Y; Huang, Y; Liu, D; Jia, S; Xu, D; Wu, M; Zhou, Y; Zhou, S; Yang, C*. “Target-responsive ‘Sweet’ Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-glucose Targets.” J. Am. Chem. Soc., 2013, 135, 3748-3751. (Cover paper & JACS Spotlights)

[32]  Han, D#; Zhu, Z#; Wu, C; Peng, L; Zhou, L; Gulbakan, B; Zhu, G; Williams, K R; Tan, W*. “A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer–Protein Interactions.” J. Am. Chem. Soc., 2012, 134, 20797-20804. (ACS C&EN News)

[33]  Zhu, L#; Li, C#; Zhu, Z#; Liu, D; Zou, Y; Wang, C; Fu, H; Yang, C*. “In Vitro Selection of Highly Efficient G-Quadruplex-Based DNAzymes.” Anal. Chem., 2012, 84, 8383-8390.

[34]  Wu, J; Wang, C; Li, X; Song, Y; Wang, W; Li, C; Hu, J; Zhu, Z*; Li, J; Zhang, W; Lu, Z*; Yang, C*. “Identification, Characterization and Application of a G-Quadruplex Structured DNA Aptamer against Cancer Biomarker Protein Anterior Gradient Homolog 2.” Plos One, 2012, 7, e46393. 

[35]  Li, C#; Zhu, L#; Zhu, Z#; Fu, H; Jenkins, G; Wang, C; Zou, Y; Lu, X; Yang, C*. “Backbone Modification Promotes Peroxidase Activity of G-Quadruplex-Based DNAzyme.” Chem. Commun., 2012, 48, 8347-8349.

[36]  Zhu, Z#; Zhang, W#; Leng, X#; Zhang, M; Guan, Z; Yang, C*. “Highly Sensitive and Quantitative Detection of Rare Pathogens through Agarose Droplet Microfluidic Emulsion PCR at the Single-Cell Level.” Lab Chip, 2012, 12, 3907-3913.

[37]  Zhu, Z; Jenkins, G; Zhang, W; Zhang, M; Guan, Z; Yang, C*. “Single-Molecule Emulsion PCR in Microfluidic Droplet.” Anal. Bioanal. Chem., 2012, 403, 2127-2143.

[38Song, Y; Zhang, W; An, Y; Cui, L; Yu, C; Zhu, Z*; Yang, C*. “Label-free Visual Detection of Nucleic Acids in Biological Samples with Single-Base Mismatch Detection Capability.” Chem. Commun., 2012, 48, 576–578.

[39]  Pu, Y#; Zhu, Z#; Han, D#; Liu, H; Liu, J; Liao, J; Zhang, K; Tan, W*. “Insulin-Binding Aptamer-Conjugated Graphene Oxide for Insulin Detection.” Analyst, 2011,47, 4138-4140. 

[40]  Wang, C#; Zhu, Z#; Song, Y; Lin, H; Yang, C*; Tan, W*. “Caged Molecular Beacons: Controlling Nucleic Acid Hybridization with Light.” Chem. Commun., 2011, 47, 5708-5710.

[41]  Zhu, Z; Wu, C; Liu, H; Zou, Y; Zhang, X; Kang, H; Yang, C*; Tan, W*. “An Aptamer Cross-linked Hydrogel as a Colorimetric Platform for Visual Detection.” Angew. Chem. Int. Ed., 2010, 49, 1052-1056. (Frontipiece Paper)

[42]  Zhu, Z; Yang, R; You, M; Zhang, X; Wu, Y; Tan, W*. “Single-walled Carbon Nanotube as an Effective Quencher.” Anal. Bioanal. Chem., 2010, 396, 73-83.

[43]  Zhu, Z; Tang, Z; Phillips, J A; Yang, R; Wang, H; Tan, W*. “Regulation of Singlet Oxygen Generation Using Single-Walled Carbon Nanotubes.” J. Am. Chem. Soc., 2008, 130, 10856-10857.