Wu Yuqi



  • Office Location: Room 326, 534 Research Dr
  • Email Address: yw586@duke.edu



Aug. 2023 - Present, Duke University, NC, USA

Ph.D. in Mechanical Engineering and Material Science

Advisor: Prof. Tony Jun Huang

Sept. 2020 - Jun. 2023, Xiamen University (XMU), Xiamen, China

Master of Chemical Biology (specialized in aptamer design and biosensing) 

Sept. 2016 - Jun. 2020, Huazhong University of Science and Technology (HUST), Wuhan, China

Bachelor of Biology (specialized in molecular biology)



  • (Leader) Bifunctional GalNAc-Aptamer chimeras mediate the targeted degradation            of extracellular and membrane proteins, XMU                       

    Advisers: Pro. Zhi Zhu

    Developed the first aptamer-based LYTACs (Apt-LYTACs) to realize the extracellular and membrane proteins’ liver cell-specific degradation by conjugating aptamers to tri-GalNAc.

    Responsible for most of the data analysis and manuscript writing.


  • (Leader) HCR-Cas12a bi-aptasensor for ultrasensitive tumour exosomes analysis, XMU   

    Advisers: Pro. Zhi Zhu

    Independently designed and achieved ultrasensitive exosomal detection at room temperature in a wash-free manner by using a Crispr-Cas 12a bi-aptasensor.

    Currently organizing the results and drafting the manuscript for submission.



(* corresponding author)

1. Yuqi Wu, Bingqian Lin, Yinzhu Lu, Liang Li, Kunyue Deng, Huiming Zhang, Chaoyong Yang, and Zhi Zhu*, Bifunctional GalNAc-Aptamer chimeras mediate the targeted degradation of extracellular and membrane proteins. Angew. Chem. Int. Ed.2023, DOI: 10.1002/anie.202218106. (IF:16.8)

2. Bingqian Lin, Yanmei Lei, Junxia Wang, Lin Zhu, Yuqi Wu, Huimin Zhang, Lingling Wu, Peng Zhang*, and Chaoyong Yang*, Microfluidic-Based Exosome Analysis for Liquid Biopsy, Small Methods. 2020, 5, 2001131. (IF:15.3)



¨      China National Scholarship                                                                                                10/2017

¨      Merit Student at HUST (1%)                                                                                              10/2017

¨      Excellent Graduate Student of HUST                                                                                     06/2020