Ke Li

CONTACT INFORMATION:

  • Office Location: Room 326, 534 Research Dr
  • Email Address: ke.li0503@duke.edu
  • Office Phone: (+1) 9842158679

 

EDUCATION:

Sept. 2016 - June. 2022, Chongqing University, China

Ph.D. in Biomedical Engineering  

Sept. 2012 - June. 2016, Chongqing University, China

B.S. in Bioengineering

 

Research Interests:

Acoustofluidics；Biomaterials and tumor therapy

 

PROFESSIONAL ACTIVITIES:

  • The targeted compound nano-enzyme system impairs the dual regulatory pathway for sensitized ferroptosis.   09/2020-09/2021     Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, China, advisor: Prof. KaiyongCai.                   
  • Functional nanosheets based on tumor microenvironment responsive degradation for activation ferroptosis in liver cancer.     08/2019-09/2020     Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, China, advisor: Prof. Kaiyong Cai.
  • Nanoplatform regulated tumor immunosuppressive microenvironment for tumor  chemo-immunotherapy.       09/2018-09/2019     Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, China, advisor: Prof. Kaiyong Cai.
  • Targeted nanoplatform repolarize the tumor-associated macrophage phenotypes for immune activation  in TNBC.    09/2017-08/2018     Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, China, advisor: Prof. Kaiyong Cai.
  • Combination of small molecule drugs to overcome hypoxic resistance of chemotherapeutic drugs in solid tumors.      09/2016-08/2017     Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, China, advisor: Prof. Kaiyong Cai. 

JOURNAL PUBLICATIONS:

  1. Ke Li†, Kun Xu†, Shaopeng Liu, Ye He*, Meijun Tan, Yulan Mao, Yulu Yang, Jing Wu,  Qian Feng, Zhong Luo, and Kaiyong Cai* All-in-One Engineering Multifunctional Nanoplatforms for Sensitizing Tumor Low-Temperature Photothermal Therapy In Vivo. ACS Nano 17(2023), 20218-20236.
  2. Ke Li, Kun Xu, Ye He, Yulu Yang, Meijun Tan, Yulan Mao, Yanan Zou, Qian Feng, Zhong Luo, Kaiyong Cai, Oxygen Self-Generating Nanoreactor Mediated Ferroptosis Activation and Immunotherapy in Triple-Negative Breast Cancer. ACS Nano 17(2023), 4667-4687.
  3. Ke Li, Chuanchuan Lin, Menghuan Li, Kun Xu, Ye He, Yulan Mao, Lu Lu, Wenbo Geng, Xuemin Li, Zhong Luo, Kaiyong Cai, Multienzyme-like Reactivity Cooperatively Impair Glutathione Peroxidase 4 and Ferroptosis Suppressor Protein 1 Pathways in Triple-Negative Breast Cancer for Sensitized Ferroptosis Therapy. ACS Nano 16(2022), 2381–2398.
  4. Ke Li, Kun Xu, Ye He, Lu Lu, Yulan Mao, Pengfei Gao, Genhua Liu, Jing Wu, Yuchen Zhang, Yang Xiang, Zhong Luo, Kaiyong Cai, Functionalized Tumor‐Targeting Nanosheets Exhibiting Fe(II) Overloading and GSH Consumption for Ferroptosis Activation in Liver Tumor. Small, 17(2021):2102046.
  5. Ke Li, Chuanchuan Lin, Ye He, Lu Lu, Kun Xu, Bailong Tao, Zengzilu Xia, Rui Zeng, Yulan Mao, Zhong Luo, Kaiyong Cai, Engineering of Cascade-Responsive Nanoplatform to Inhibit Lactate Efflux for Enhanced Tumor Chemo-Immunotherapy. ACS Nano,14(2020),14164−14180.
  6. Ke Li, Lu Lu, Chencheng Xue, Ju Liu, Ye He, Jun Zhou, Liangliang Dai, Zhong Luo, Yulan Mao, Kaiyong Cai, Polarization of Tumor-Associated Macrophages Phenotype via Porous Hollow Iron Nanoparticles for Tumor Immunotherapy in vivo.  Nanoscale, 12(2019),130-144. (High cited)
  7. Ke Li, Menghuan Li, Zhong Luo, Yulan Mao, Yonglin Yu, Ye He, Jun Zhou, Yang Fei, Yuxia Pei, Kaiyong Cai, Overcoming the hypoxia-induced drug resistance in liver tumor by the concurrent use of apigenin and paclitaxel. Biochemical and Biophysical Research Communications, 526(2020) 321-327.

AWARDS AND HONORS:

1. National Scholarship of China (2016)

2. Outstanding postgraduate of Chongqing University (2018)

3. National Scholarship of China (2020)

4. Outstanding postgraduate of Chongqing University (2020)

5. Outstanding graduate student of Chongqing University (2021)

6. National Scholarship of China (2021)

7. Outstanding graduate student of Chongqing (2022)